Yes! Though some things are easier to move than others.
Moving widget content (see our article on Working with Widgets) is literally as simple as dragging and dropping. Moving most other blocks of content involves delving into your site’s CSS (Cascading Style Sheet) code. It’s definitely doable, but you’ll need to invest a little time into learning the lingo and how to apply it to your site’s content. Our article will help you get started — the rest is limited only by your curiosity and ingenuity!